Named from the Greek word ps?ra meaning "itch," the term ‘psoriasis’ encompasses a set of chronic inflammatory autoimmune dermatoses which requires lifelong care. It is a chronic, non-communicable inflammatory disease which is often mistaken for contagious diseases, such as leprosy, syphilis and even HIV/AIDS. In 2014, WHO member states recognized psoriasis as a serious non-communicable disease (NCD) in the World Health Assembly resolution WHA67.9. The resolution highlighted that many people in the world suffer needlessly from psoriasis due to incorrect or delayed diagnosis, inadequate treatment options and insufficient access to care, and because of social stigmatization. There are no special blood tests or tools to diagnose psoriasis.
There are several clinical types of psoriasis including plaque psoriasis, guttate psoriasis, Intertriginous psoriasis / inverse psoriasis, pustular psoriasis and erythrodermic psoriasis. Although clinical findings in patients frequently overlap in different types of psoriasis, each type of psoriasis may require different treatment approach. The exact cause of psoriasis isn’t fully understood, but researchers believe psoriasis is the result of several factors, including genetics, environmental factors, and the immune system. Researchers come to an understanding that psoriatic disease is an autoimmune inflammatory disease which means that psoriasis and psoriatic arthritis are actually caused by an overactive immune system. The immune stimulation of epidermal keratinocytes; T cells appear to play a key role. There is emerging evidence that psoriasis patients have a higher prevalence of associated comorbid disease with cardiometabolic dysfunction and psoriatic arthritis being at the forefront. Between 1.3 percent and 34.7 percent of individuals with psoriasis develop chronic, inflammatory arthritis (psoriatic arthritis) that leads to joint deformations and disability. Between 4.2 percent and 69 percent of all patients suffering from psoriasis develop nail changes.
There are more than 140 million people, or nearly 3 percent of the world's population, men, women, and children, even newborn babies, who suffer from psoriasis. As per 2016 WHO report on psoriasis, the reported prevalence of psoriasis in countries ranges between 0.09 percent and 11.4 percent, making psoriasis a serious global problem. It is estimated that at least 10 percent of psoriasis sufferers have a severe form that causes disability and exclusion from a normal life. Economically, in the U.S. alone, impact is estimated that Americans with psoriasis lose approximately 56 million hours of work and spend in billions to treat the disease every year.
There are no curative treatments available for many chronic dermatological conditions, like psoriasis. Psoriasis is a clinically heterogeneous disease, and its individual presentation can make the selection of the most appropriated treatment difficult. The best treatment is individually determined by the treating doctor and depends, in part, on the type of disease, the severity, and amount of skin involved. Inflammation plays an important role in the pathophysiology of Psoriasis and hence most of the treatment options are targeted towards alleviating inflammation in psoriasis.
The global psoriasis market size was valued at USD9.62 billion in 2017 and is estimated to grow at a rate of 8.7 percent during the forecast period and will reach USD20.3 billion by 2026. The currently available therapeutic options for psoriasis include several treatment approaches such as topical corticosteroids, vitamin D derivatives, retinoids, systemic small molecule immunosuppressing agents, phototherapy, and systemic biologics. The market is driven by increasing prevalence of psoriasis and psoriatic arthritis, although the exact pathologic reason for this is not clear, the rising prevalence of risk factors and co-morbidities over the same time period is another likely contributory factor. In addition to this, we see improved diagnostic and patient awareness playing a critical role in increasing prevalence of psoriasis and favorable regulatory and reimbursement policy modifications over the past five years. However, high out-of-pocket costs, restrictive coverage policies, frequent denials and an overall lack of understanding about treatment options create roadblocks for patients trying to access treatments and medications for psoriasis. The market has witnessed the ‘blockbuster’ success of Stelara, Enbrel and Humira, which is motivating the Psoriasis market players to develop newer, more efficacious biologics having improved efficacy and safety parameters compared to earlier ‘blockbuster’ biologics.
Even though past few years have seen the advent of numerous new medications for the treatment of psoriasis, there still is considerable room for improvement in our treatment of this condition. Novel insights into the underlying mechanisms of psoriasis have yielded exciting new potential medications, many with promising preliminary efficacy data. There are multiple new breakthroughs we may see in the near future which may include molecules with novel mechanisms and more effective dosage forms. Global psoriasis pipeline comprised of total 224 programs at various stages of clinical development.
Key Questions Answered and insights delivered in the Report:
- Detailed disease overview of psoriasis.
- Global epidemiology of psoriasis. (major regions covered are the US, EU5, Japan, and India).
- Global dermatology market; 2016-2026. (major regions covered are the US, EU5, Japan, and India).
- Global psoriasis market; 2016-2026. (major regions covered are the US, EU5, Japan, and India).
- Current treatment landscape of psoriasis.
- Classification of treatment options of psoriasis.
- Pipeline analysis of psoriasis.
- Detailed analysis of promising drugs in clinical development.
- Key unmet needs in psoriasis.
- Growth drivers, future opportunities and challenges in the market.
- Company profile of key players.
Executive Summary
Key Questions Answered
1. Psoriasis: Disease Overview
I. Etiology and Pathophysiology
II. Psoriasis Triggers
a. Emotional stress
b. Injury /Sunburn
c. Drugs
d. Obesity
e. Food/ Smoking and Alcohol
III. Clinical Types and Symptoms
a. Prototype Lesion
b. Clinical Types
Plaque Psoriasis
Guttate (Eruptive) Psoriasis
Scalp Psoriasis
Flexural (inverse, intertriginous) Psoriasis
Pustular Psoriasis
Erythrodermic Psoriasis
Nail Psoriasis
c. Other Forms
Acral Psoriasis / Palmoplantar Psoriasis
d. Symptomss
IV. Comorbidities Associated
a. Psoriatic arthritis (PsA)
b. Cardio-metabolic Disorders
c. Psychosocial Disorders
2. Epidemiology
I. Global Epidemiology Trends of Psoriasis
a. Global Epidemiology of Psoriasis
II. US Epidemiology of Psoriasis
III. EU5 Epidemiology of Psoriasis
a. Germany Epidemiology of Psoriasis
b. UK Epidemiology of Psoriasis
c. France Epidemiology of Psoriasis
d. Spain Epidemiology of Psoriasis
e. Italy Epidemiology of Psoriasis
III. Japan Epidemiology of Psoriasis
IV. India Epidemiology of Psoriasis
3. Treatment
I. Topical
a. Topical Corticosteroids
b. Topical Vitamin D Analogues
c. Other Topical Products
Tazarotene
Dithranol and Coal Tar
d. Phototherapy
e. Systemic Non-Biologics
f. Oral Treatments
Systemic Immunosuppressive Drugs (Cyclosporine, methotrexate and azathioprine)
Methotrexate
Cyclosporine
Oral Calcineurin Inhibitors (Tacrolimus, Pimecrolimus, Voclosporine)
Retinoids
Apremilast
Systemic Steroids
Systemic Biologics
Tumor Necrosis Factor-alpha (TNF-alpha) Inhibitors
Interleukin 12 and 23 (IL-12/23) Inhibitors
Interleukin 17 (IL-17) Inhibitors
Interleukin 23 (IL-23) Inhibitors
4. Dermatology Market Outlook and Forecast
I. Global Dermatology Market Outlook
II. US Dermatology Market Outlook
III. EU5 Dermatology Market Outlook
IV. Japan Dermatology Market Outlook
V. Indian Dermatology Market Outlook
5. Psoriasis Market Outlook and Forecast
I. Global Psoriasis Market Outlook
II. US Psoriasis Market Outlook
III. EU5 Psoriasis Market Outlook
a. Germany Psoriasis Market Outlook
b. France Psoriasis Market Outlook
c. UK Psoriasis Market Outlook
d. Italy Psoriasis Market Outlook
e. Spain Psoriasis Market Outlook
IV. Japan Psoriasis Market Outlook
V. Indian Psoriasis Market Outlook
VI. Key Approved Products and Forecast:
a. Stelara Psoriasis Market Forecast
b. Enbrel Psoriasis Market Forecast
c. Humira Psoriasis Market Forecast
d. Otezla Psoriasis Market Forecast
e. Cosentyx Psoriasis Market Forecast
f. Taltz Psoriasis Market Forecast
g. Tremfya Psoriasis Market Forecast
6. Pipeline Analysis
I. Pipeline Analysis – Biosimilars
II. Key Molecules in Pipeline
a. Small Molecules
b. Reformulations/ New Combinations
c. New Biologics
7. Market Drivers
I. Rising Prevalence
II. Novel Pipeline Addressing Unmet Needs
III. Favorable Regulatory and Reimbursement Policies
8. Unmet Needs
I. Long-term Safety or Tolerability and Ef?cacy
II. Lack of Innovative Dosage Forms
III. Associated Psychological Implications
IV. Higher Cost of Effective Therapy
9. Potential Opportunities
I. Novel Drug Delivery Systems: Topical Products
a. Aqueous and Emollient Foams
b. Micro and Nano Lipid Carriers
c. Polymeric Carriers
d. Micro and Nanoemaulsions
e. Meso or Nanoporous Microparticles
f. Dosage Form for Sensitive Skin Areas
10. Company Profile
I. Amgen
a. Business Overview
b. Financial Overview
II. AbbVie
a. Business Overview
b. Financial Overview
III. Sun Pharmaceuticals
a. Business Overview
b. Financial Overview
IV. Valeant Pharmaceuticals
a. Business Overview
b. Financial Overview
About EffeMarket
Disclaimer
Figure 1.1 Comparison of Psoriasis Skin vs. Normal Skin
Figure 1.2 Psoriasis Classification by Severity
Figure 1.3 Pathophysiology of Psoriasis
Figure 1.4 Triggers of Psoriasis
Figure 1.5 Potential Comorbidities Associated with Psoriasis
Figure 2.1 Global Prevalence of Psoriasis; 2017-2026
Figure 2.2 US Prevalence of Psoriasis; 2017-2026
Figure 2.3 Germany Prevalence of Psoriasis; 2017-2026
Figure 2.4 UK Prevalence of Psoriasis; 2017-2026
Figure 2.5 UK Prevalence of Psoriasis; 2017-2026
Figure 2.6 Spain Prevalence of Psoriasis; 2017-202
Figure 2.7 Italy Prevalence of Psoriasis; 2017-2026
Figure 2.8 Japan Prevalence of Psoriasis; 2017-2026
Figure 2.9 India Prevalence of Psoriasis; 2017-2026
Figure 3.1 Classification of Treatment Options of Psoriasis
Figure 4.1 Global Dermatology Market; 2017-2026
Figure 4.2 US Dermatology Market; 2017-2026
Figure 4.3 EU5 Dermatology Market; 2017-2026
Figure 4.4 Japan Dermatology Market; 2017-2026
Figure 4.5 India Dermatology Market; 2017-2026
Figure 5.1 Global Psoriasis Market; 2017-2026
Figure 5.2 US Psoriasis Market; 2017-2026
Figure 5.3 EU5 Psoriasis Market; 2017-2026
Figure 5.4 Germany Psoriasis Market; 2017-2026
Figure 5.5 France Psoriasis Market; 2017-2026
Figure 5.6 UK Psoriasis Market; 2017-2026
Figure 5.7 Italy Psoriasis Market; 2017-2026
Figure 5.8 Spain Psoriasis Market; 2017-2026
Figure 5.9 Japan Psoriasis Market; 2017-2026
Figure 5.10 India Psoriasis Market; 2017-2026
Figure 5.11 Sales of Stelara (Ustekinumab) for Psoriasis; 2017-2026
Figure 5.12 Sales of Enbrel (Etanercept) for Psoriasis; 2017-2026
Figure 5.13 Sales of Humira (Adalimumab) for Psoriasis; 2017-2026
Figure 5.14 Sales of Otezla (Apremilast) for Psoriasis; 2017-2026
Figure 5.15 Sales of Cosentyx (Secukinumab) for Psoriasis; 2017-2026
Figure 5.16 Sales of Taltz (ixekizumab) for Psoriasis; 2017-2026
Figure 5.17 Sales of Tremfya (guselkumab) for Psoriasis; 2017-2026
Figure 6.1 Psoriasis Pipeline by Stage of Development; 2017
Figure 6.2 Psoriasis Pipeline by Molecule Type; 2017
Figure 6.3 Psoriasis Pipeline by Targets; 2017
Figure 6.3 Emulsion Droplet vs. PAD Droplet
Figure 6.4 Deposition of Lipids
Figure 6.5 Tildrakizumab Mechanism of Action
Figure 8.1 Key Unmet Needs in Psoriasis
Figure 9.1 Key Topical Novel Drug Delivery Systems
Figure 9.2 Various Foam Technologies
Figure 10.1 Amgen Revenue; 2012-2016
Figure 10.2 Amgen Product Sales; 2016
Figure 10.3 AbbVie Revenue; 2012-2016
Figure 10.4 AbbVie Product Sales; 2016
Figure 10.5 Sun Pharmaceuticals Revenue; 2013-2017
Figure 10.6 Sun Pharmaceuticals R&D Expenditure; 2013-2017
Figure 10.7 Valeant Pharmaceuticals Revenue; 2012-2016
Figure 10.8 Valeant Pharmaceuticals Revenue by Segments; 2012-2016
Table 2.1 Global Epidemiology of Psoriasis; 2017
Table 5.1 Commercially Available products in EU5 Psoriasis Market
Table 6.1 Novel Molecule Pipeline for Treatment of Psoriasis
Table 6.2 Biosimilars Pipeline for Treatment of Psoriasis